Content reviewed by the PillRelax Healthcare Team | Last reviewed: September 2026
Diazepam, sold under the brand name Valium, is one of the most widely recognised medicines in the world. It has been prescribed in the UK for decades for anxiety, muscle spasms, and alcohol withdrawal.
What Is Diazepam?
Diazepam is a long-acting benzodiazepine medicine. It is a prescription-only medicine (POM) in the UK, classified as a Schedule 4 controlled drug under the Misuse of Drugs Act 1971. It is available in tablet form at 2mg, 5mg, and 10mg strengths.
How Does Diazepam Work?
Diazepam enhances the effect of GABA at the GABA-A receptor in the brain. GABA is the main inhibitory neurotransmitter, reducing neuronal activity across the central nervous system. This produces anxiolytic (anti-anxiety), sedative, muscle relaxant, and anticonvulsant effects.
What Is Diazepam Used For in the UK?
- Short-term relief of severe anxiety (2-4 weeks maximum per NICE guidelines)
- Muscle spasms and spasticity
- Alcohol withdrawal syndrome
- Premedication before medical procedures
- Status epilepticus (IV or rectal form)
UK Dosage Reference
| Indication | Standard Dose | Max Duration |
|---|---|---|
| Anxiety | 2-10mg, 2-4 times daily | 2-4 weeks |
| Muscle spasm | 5-10mg, 3 times daily | Short-term |
| Over 65 years | Half standard dose | 2-4 weeks |
Source: NICE BNF Diazepam monograph
Dependence and Withdrawal
Diazepam carries significant dependence risk. Physical dependence can develop within weeks. Abrupt discontinuation after prolonged use can cause a dangerous withdrawal syndrome including seizures. Any dose reduction should be gradual and medically supervised.
How Long Does Diazepam Stay in Your Body?
Diazepam has a long half-life of 20-100 hours. Its active metabolite (desmethyldiazepam) has a half-life of up to 200 hours. A single dose can remain detectable for several days.
Frequently Asked Questions
Is Diazepam the same as Valium?
Yes. Valium is the original brand name for Diazepam. They are therapeutically equivalent at the same dose.
Where can I buy Diazepam in the UK?
Diazepam is available from regulated UK pharmacies with a valid prescription. Learn how to order Diazepam from PillRelax
