Content reviewed by the PillRelax Healthcare Team | Last reviewed: September 2026
Pregabalin is a prescription medicine used for nerve pain, epilepsy, generalised anxiety disorder, and fibromyalgia. It has become one of the most prescribed medicines in England.
What Is Pregabalin?
Pregabalin (brand name: Lyrica) is an anticonvulsant and analgesic belonging to the gabapentinoid class. In the UK, it has been a Class C controlled drug since 2019.
What Is Pregabalin Used For?
- Neuropathic pain – diabetic neuropathy, post-herpetic neuralgia, spinal cord injury pain
- Fibromyalgia – widespread musculoskeletal pain with fatigue
- Generalised Anxiety Disorder (GAD) – alternative to benzodiazepines
- Epilepsy – adjunctive treatment for partial seizures
How Does Pregabalin Work?
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels, reducing calcium influx into neurons and thereby reducing the release of excitatory neurotransmitters including glutamate, noradrenaline, and substance P.
UK Dosage
For neuropathic pain, typical UK doses range from 150mg to 600mg daily in divided doses. Treatment usually starts at 75mg twice daily and is titrated upward. Source: NICE BNF Pregabalin.
Frequently Asked Questions
Is Pregabalin addictive?
Yes – physical dependence can develop, and withdrawal symptoms can occur with abrupt discontinuation. Dose reduction should always be gradual under medical supervision.
Is Pregabalin the same as Gabapentin?
They are related (both gabapentinoids) but Pregabalin has greater bioavailability and more predictable absorption. Pregabalin is generally considered more potent.
